This is just a portrait of an unfortunate woman. Unfortunate because she’s lived just a bit too long and has grown to resemble some horror-trope crone. Unfortunate because she’s clearly suffering from some bizarre health issues. Unfortunate because she does not have access to care to correct these issues. And perhaps most unfortunate of all, because she has given her body over to demons who now walk the Earth in human skin, only distinguishable by their black eyes and the goddamn horns growing out of their heads.
This is most likely a common skin condition called a cutaneous horn, which is basically just compacted keratin — the same protein in hair and nails — protruding from the epidermis. If this is indeed a cutaneous horn, they’re often benign and can usually be removed surgically. Though that does not treat the underlying cause, which is either excessive sun exposure to already damaged skin, or the devil coming to live inside the empty shells left behind by suicides.