What is allopurinol? Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment. Allopurinol may also be used for purposes not listed in this medication guide.
Important information about allopurinol
Do not use allopurinol if you have ever had a serious allergic reaction to allopurinol. Stop taking the medicine and call your doctor at once if you have any signs of skin rash, no matter how mild. Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise. Allopurinol can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly. Avoid drinking alcohol. It can make your condition worse. Allopurinol or zyloprim 100mg may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Before taking allopurinol
To make sure you can safely take allopurinol, tell your doctor if you have any of these other conditions:
FDA pregnancy category C. It is not known whether allopurinol 300 mg will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Allopurinol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take allopurinol?
Take allopurinol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Take each dose with a full glass of water. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise. You may have gout attacks more often when you first start taking allopurinol or zyloprim 300 mg. Your doctor may recommend other gout medication to take with allopurinol. Keep using your medication as directed and tell your doctor if your symptoms do not improve after a few months of treatment. Allopurinol or zyloprim 200mg can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly. Store allopurinol at room temperature away from moisture and heat.
What should I avoid while taking allopurinol?
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Allopurinol may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid drinking alcohol. It may worsen your condition. Your doctor may recommend a special diet to help treat your condition. Follow your diet and medication routines very closely.
Allopurinol dosage Information
Usual Allopurinol Adult Dose for Gout:
Initial: allopurinol 100mg orally once a day. Maintenance: 200 to 300 mg (mild gout) orally once a day or 400 to 600 mg/day (moderately severe tophaceous gout) in divided doses.
Usual Allopurinol Adult Dose for Hyperuricemia Secondary to Chemotherapy:
Initial: Parenteral: 200 to 400 mg/m2/day to a maximum of 600 mg/day Oral: 600 to 800 mg/day for 1 to 3 days with consumption of at least 2 L of fluid/day.
Maintenance: 200 to 300 mg/day orally until patient no longer at high risk for developing hyperuricemia.
Usual Allopurinol Adult Dose for Calcium Oxalate Calculi with Hyperuricosuria:
Initial: 200 to 300 mg orally once a day. Maintenance: 300 mg/day or less.
Usual Adult Dose for Congestive Heart Failure:
Study (n=11) to prevent the formation of superoxide free radicals and improve endothelial function (in NYHA class II to III chronic heart failure): 300 mg orally daily for 1 month
Usual Allopurinol Adult Dose for Cardiothoracic Surgery:
Studies: Coronary Artery Bypass Graft Surgery 600 mg orally one day prior to surgery and another 600 mg orally the day of surgery.