Skooter reporting 08/25/12
It would take perhaps at least two decades for inherited forms of Alzheimer’s disease to show evident before problems with memory and thinking develop. This is a promising breakthrough that could lead the way to better treatment of this upsetting disease.
The findings are important because, by the time dementia symptoms pops out, the disease has seriously damaged the brain, making it nearly impossible to restore mental abilities and memories.
At the Washington University School of Medicine in St. Louis, researchers have been at worked in an international study investigating at inherited forms of Alzheimer's.
The researchers are monitoring members of families who have mutations in one of three genes: amyloid precursor protein; presenilin 1; or presenilin 2. People with these mutations will develop Alzheimer's disease early, between their 30s and their 50s, previous research has indicated.
The researchers have discovered a method to determine the age of disease inception among study participants by mentioning their parents. For example, if a parent acquired dementia at the age of 50 years, a child who inherited the mutation would most likely to develop dementia more or less the same age. Accordingly, scientists have been able to follow disease succession, counting the many years Alzheimer's is active in people's brains but warning sign are not yet noticeable.
Fascinatingly, primary results of the study prove that certain alterations in spinal fluid could be distinguished years before dementia.
Based on what they have observed in their study population, the researchers have come to the conclusion so far that brain chemistry modifications can be detected up to 20 years before the estimated age of symptom start. And, they ended, these Alzheimer's-related changes can be specifically aimed for preventative therapies.
Alzheimer's disease afflicts the mind, progressively causing mental decline and dementia. Unfortunately, up to now, there is no recovery for those who have this degenerative disease of the brain. The disease attacks nerve cells in the brain, causing the person to lose control of their emotions, movement and memory. It is a frustrating and painful disease, both for the person living with Alzheimer's and the people they love. This long-term disorder by and large affects people over the age of 65 and is now the fourth leading cause of death in adults.