Good Effects of Experimental Drugs to Autism-Like symptom in Mice

Good Effects of Experimental Drugs to Autism-Like symptom in Mice

Los Angeles : CA : USA | Apr 29, 2012 at 4:15 AM PDT
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A study published in the Journal Science Translation Medicine suggest that researchers identified a novel experimental drug compound that improved autism found likely to symptoms in mice.

The research study was published in the Journal Science Translation Medicine.

The discovery of significant effects of GRN-529 , which inhibit the actions of a glutamate, a chemical use to assemble protein in the brain, leads to a hope that strengthens the case of relevance that this class of agent could possible target the different types of diagnostic symptoms of autism to humans like what have resulted the experimentation conducted in mice.

When the experimental agent is tested to mice and it caused them to increase their social interactions and decreased their repetitive self-grooming behaviour.

The study is conducted by the researchers from the National Institutes of Mental Health (NIMH) and Pfizer Worldwide Research and Development.

Autism, a mental disorder, is caused by mutations in genes that control the formation and maturation of the connections between neurons. The core symptoms of autism spectrum disorders are lack of social interactions and repetitive behaviours.

While findings in mice are not often can be translated to humans and the research about this experimental compound is in the too early stage, Jill Silverman of the NIHM, the lead researcher said that the data is encouraging since it strengthens medical findings for relevance.

She said that though the study was just the first step in the long process of finding the cure for autism, the findings are very significant since there is no drug right now that is available to autistic patients that deal with any of the core symptoms of autism. The current drugs that are prescribed are just for self-injuries and irritability which can lead to tantrums.

Risperdal and Abilify are approved drugs which are anti-psychotics but can have dangerous side effects, according to her.

The mice tested in study show symptoms that strongly resemble to autism. The mice are commercially bred. Based on the behaviour of the mice, they have a very low social interaction and increased repetitive self-grooming so excessively that in some cases, their hair fall out.

Just like the communication deficit often seen in people diagnosed with autism, the mice also have not vocalized much in the study.

But as the researchers gave GRN-529 to mice, they groomed themselves less and increase their social interaction with other mice. Some other groups of mice also displayed less repetitive jumping.

Ashley Miller, a writer by heart and a thoughtful wife, likes to dip in a hot tub for a couple of minutes while relieving her occasional migraine. When she feels tired, she also bath in a Jacuzzi spa. The way I see it, she is very thankful of having the facility.

ashleymiller is based in Los Angeles, California, United States of America, and is a Stringer on Allvoices.
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