The discovery will improve and personalize treatments. "From a clinical perspective and biologically, its a dozen different diseases, "explained
Two dozen researchers from the universities of Cambridge , UK, and, Canada, was able to identify ten subtypes of breast cancer, as well as some of the genetic and molecular differences between them.
The study, whose findings published on Wednesday the British science journal Nature, was to analyze the DNA of 2,000 tumors using the latest technology X-ray for five years.
"The breast cancer is not just a disease, but ten different diseases, really different from each other from a clinical perspective and biological, as distinct genes involved in them. This is a completely new perspective, "said Dr. Portuguese Carlos Caldas, University of Cambridge, who led the research.
Moreover, it uncovered several dozens of genes involved in the table so far unknown, which could serve as a target for new therapies in the future.
The finding will help develop personalized treatments, consisting of evaluating factors such as genetic information, family history and patient history, for each type of breast cancer.
Only one of the ten subtypes identified, scientists found a significant presence of an inherited gene, called BRIC1, which creates a predisposition to the tumor.
During the investigation, experts determined that the immune system can recognize the presence of the disease and try to fight it. "Surprisingly, in this case we observe an interesting activity of lymphocytes, suggesting that the body reacts," said Caldas.
That finding applies only to a type of sub cancer. "If we could figure out why these tumors in the immune system are activated, we could try to find ways to encourage him to fight other types of breast cancer," said the specialist.
So far, investigations of breast cancer and its causes were at a very early, as to results to be meaningful it must use a very large sample of patients. The findings of this study amounts to find "a new map to navigate the best, both in clinical and laboratory.”