Italian researchers found how to stop low back pain in a new study from the Catholic University of Rome. Check out the study or its abstract published in the journal Spine in its February 16, 2012 online edition. Also see the March 13, 2011 news release, "Italian researchers found how to stop low back pain." Scientists found the the molecular mechanism responsible for vertebral column degeneration. The study looked at low back pain in mice. Can the findings be of help to humans? Check out the journal Spine | LWW. Also see Back Pain, Neck Pain, Lower Back Pain | Spine-Health.
Italian researchers at the Catholic University of Sacred Heart in Rome found an important molecular mechanism responsible for low back pain and other acute vertebral problems like cervical axial pain, all due to aging and degeneration of the vertebral column. The team led by Dr. Luigi Aurelio Nasto and Enrico Pola also developed an experimental drug to inhibit this degenerative mechanism, by blocking its principal culprit, the molecule, "NF-kB" and tested it successfully in mice. The study was carried out in collaboration with the University of Pittsburgh research team led by Paul Robbins, James Kang and Nam Vo (e-mail: firstname.lastname@example.org).
Nasto and Pola found that high concentration of NF-kB causes the degeneration of intervertebral discs (the structures that separate and damp the vertebrae), a degenerative process that could affect also young adults (30 year old), especially if they adopt a sedentary lifestyle. In other words when NF-kB becomes overactive, it triggers a series of deleterious reactions that ultimately affect the physiological structure of the vertebral column.
Due to aging, obesity and sedentary lifestyle, intervertebral discs degenerate, leading to the progressive stiffening of the column. The intervertebral disc degeneration is responsible for syndromes such as chronic low back pain or neck pain that affects a large proportion of the adult population.
Back pain and neck pain are ranked among the leading causes of lost working hours and disability in adults Italian scientists found the mechanism behind the degenerative processes of the column. They studied mice that are genetically programmed to age rapidly (progeroid mice).
Also see the March 13, 2012 news release, Cool hands may be the key to increasing exercise capacity. Researchers found that cooling the palms of the hands while working out could help you stick with a physical activity program, according to a small study presented at the American Heart Association's Epidemiology and Prevention/Nutrition, Physical Activity and Metabolism 2012 Scientific Sessions. The study was done by the Cardiovascular Institute, Women's Health at Stanford University.
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