Heidi, the name of the opossum with squint eyes on each cause fever, died after being treated for several weeks illness.
"The beast has opot Heidi eyes squint eye forever," News for notification of the zoo's leadership in the eastern city of Leipzig in Germany.
Heidi, three and a half years, battling health problems and could not walk for weeks.
"We have taken every measure to test the treatment and cure for Heidi. Finally we decided to end the suffering endured by Heidi for it to sleep forever", Joerg Junhold, director Leipzig Zoo, said.
When Heidi is alive "star" on both Facebook and Twitter. On Facebook it is up to 332,963 fans.
A few minutes after news of the death of Heidi spread, fans on Twitter and Facebook have organized the funeral for it, The Washington Post said.
"Buon do. Lovely creature makes our lives richer. It proves that the imperfect is also a very interesting and beautiful," Rene Schaaf, who live in the city of Leipzig,wrote on Facebook.
Heidi became famous after a reporter for the newspaper Bild photographing animals in zoos in Leipzig. After the image appears in the press, it quickly attracted the attention of public opinion.
It had picked up Heidi with "sister" Naira of it outside of the animal rescue center in the state of North Carolina, USA. Then we were taken to Germany in May last year.
A musician named Stefan Langner composed a song about Heidi and the girls showed the song. When the music's been posted on YouTube Langner, many people have visited to hear. Listen to Heidi here.